Drug interactions
Chlorpromazine + Enalapril-hydrochlorothiazide
Severity: Moderate
Chlorpromazine and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine causes orthostatic hypotension through alpha-adrenergic blockade. With an ACE inhibitor and thiazide, the blood pressure drop may be greater, increasing the risk of dizziness and falls, especially in older patients.
What this interaction means in plain words
Chlorpromazine and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade, ACE inhibition and diuresis.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing chlorpromazine. Lower the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Chlorpromazine and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine causes orthostatic hypotension through alpha-adrenergic blockade. With an ACE inhibitor and thiazide, the blood pressure drop may be greater, increasing the risk of dizziness and falls, especially in older patients.
How serious is the interaction between Chlorpromazine and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing chlorpromazine. Lower the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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