Drug interactions
Chlorpromazine + Glycopyrronium
Severity: Moderate
Chlorpromazine and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has significant antimuscarinic activity, so adding glycopyrronium increases anticholinergic burden, causing dry mouth, constipation, urinary retention, tachycardia and confusion. Reduced gut motility and heat intolerance can become clinically important.
What this interaction means in plain words
Chlorpromazine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects at peripheral and central muscarinic receptors.
What to do
Monitor for anticholinergic symptoms, bowel function and urinary retention, and reduce the dose or stop glycopyrronium if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Glycopyrronium?
MediHelp rates the interaction as moderate. Chlorpromazine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has significant antimuscarinic activity, so adding glycopyrronium increases anticholinergic burden, causing dry mouth, constipation, urinary retention, tachycardia and confusion. Reduced gut motility and heat intolerance can become clinically important.
How serious is the interaction between Chlorpromazine and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, bowel function and urinary retention, and reduce the dose or stop glycopyrronium if they emerge.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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