Drug interactions
Chlorpromazine + Histrelin
Severity: Moderate
Chlorpromazine and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, causes androgen deprivation, which can prolong the QT interval. Combined with chlorpromazine, a QT-prolonging drug, the risk of torsades de pointes may increase.
What this interaction means in plain words
Chlorpromazine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QTc prolongation, with androgen deprivation therapy contributing to repolarization delay.
What to do
Check a baseline ECG and electrolytes, and monitor QTc periodically. Consider an alternative antipsychotic with lower QT risk if the QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Chlorpromazine with Histrelin?
MediHelp rates the interaction as moderate. Chlorpromazine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, causes androgen deprivation, which can prolong the QT interval. Combined with chlorpromazine, a QT-prolonging drug, the risk of torsades de pointes may increase.
How serious is the interaction between Chlorpromazine and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor QTc periodically. Consider an alternative antipsychotic with lower QT risk if the QTc lengthens significantly.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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