Drug interactions
Chlorpromazine + Imatinib
Severity: Moderate
Chlorpromazine and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and may raise chlorpromazine concentrations. This could increase sedation, hypotension and QT-related effects, though the clinical impact is not well characterized.
What this interaction means in plain words
Chlorpromazine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP2D6, reducing chlorpromazine metabolism.
What to do
Monitor for sedation, orthostatic hypotension and extrapyramidal effects. Reduce the chlorpromazine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Chlorpromazine with Imatinib?
MediHelp rates the interaction as moderate. Chlorpromazine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2D6 and may raise chlorpromazine concentrations. This could increase sedation, hypotension and QT-related effects, though the clinical impact is not well characterized.
How serious is the interaction between Chlorpromazine and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and extrapyramidal effects. Reduce the chlorpromazine dose if adverse effects appear.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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