Drug interactions
Chlorpromazine + Isoproterenol
Severity: Moderate
Chlorpromazine and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has alpha-blocking activity that can cause vasodilation and hypotension, and a beta-agonist like isoproterenol may further lower diastolic pressure and increase heart rate. Both agents can also be arrhythmogenic in susceptible patients.
What this interaction means in plain words
Chlorpromazine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
Chlorpromazine's alpha-adrenergic blockade combined with isoproterenol's beta-mediated vasodilation may cause hypotension and reflex tachycardia.
What to do
Monitor blood pressure, heart rate and ECG during combined use. Reduce or titrate the isoproterenol dose if hypotension or arrhythmia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Chlorpromazine with Isoproterenol?
MediHelp rates the interaction as moderate. Chlorpromazine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has alpha-blocking activity that can cause vasodilation and hypotension, and a beta-agonist like isoproterenol may further lower diastolic pressure and increase heart rate. Both agents can also be arrhythmogenic in susceptible patients.
How serious is the interaction between Chlorpromazine and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG during combined use. Reduce or titrate the isoproterenol dose if hypotension or arrhythmia occurs.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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