Drug interactions
Chlorpromazine + Levetiracetam
Severity: Moderate
Chlorpromazine and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so sedation may be additive. Chlorpromazine may also lower seizure threshold, potentially reducing seizure control. Levetiracetam can cause behavioral effects that may complicate psychiatric treatment.
What this interaction means in plain words
Chlorpromazine and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depression; chlorpromazine lowers seizure threshold.
What to do
Monitor for sedation, seizure frequency and mood or behavior changes. Use the lowest effective chlorpromazine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Chlorpromazine with Levetiracetam?
MediHelp rates the interaction as moderate. Chlorpromazine and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and dizziness, so sedation may be additive. Chlorpromazine may also lower seizure threshold, potentially reducing seizure control. Levetiracetam can cause behavioral effects that may complicate psychiatric treatment.
How serious is the interaction between Chlorpromazine and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, seizure frequency and mood or behavior changes. Use the lowest effective chlorpromazine dose.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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