Drug interactions
Chlorpromazine + Linagliptin-metformin
Severity: Moderate
Chlorpromazine and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can cause hyperglycemia and weight gain and may reduce the effectiveness of metformin and linagliptin. Glycemic control can worsen, and may improve again when chlorpromazine is stopped.
What this interaction means in plain words
Chlorpromazine and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Linagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance and impaired insulin secretion.
What to do
Monitor blood glucose regularly and adjust antidiabetic doses as required; recheck control when chlorpromazine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Chlorpromazine and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can cause hyperglycemia and weight gain and may reduce the effectiveness of metformin and linagliptin. Glycemic control can worsen, and may improve again when chlorpromazine is stopped.
How serious is the interaction between Chlorpromazine and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly and adjust antidiabetic doses as required; recheck control when chlorpromazine is withdrawn.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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