Drug interactions
Chlorpromazine + Methocarbamol
Severity: Moderate
Chlorpromazine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is a strongly sedating phenothiazine, and methocarbamol adds further CNS depression. The combination can cause marked drowsiness, orthostatic hypotension and psychomotor impairment, with an increased risk of falls.
What this interaction means in plain words
Chlorpromazine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with chlorpromazine's antihistaminic and alpha-adrenergic blocking effects contributing.
What to do
Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Counsel about driving and alcohol, and reduce the dose if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Methocarbamol?
MediHelp rates the interaction as moderate. Chlorpromazine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is a strongly sedating phenothiazine, and methocarbamol adds further CNS depression. The combination can cause marked drowsiness, orthostatic hypotension and psychomotor impairment, with an increased risk of falls.
How serious is the interaction between Chlorpromazine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Counsel about driving and alcohol, and reduce the dose if impairment occurs.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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