Drug interactions
Chlorpromazine + Methoxsalen
Severity: Moderate
Chlorpromazine and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is a photosensitizing phenothiazine, and methoxsalen is used with UVA light to induce photosensitivity. Combined use can increase the risk of severe phototoxic skin reactions, burns and eye damage.
What this interaction means in plain words
Chlorpromazine and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects of the two drugs.
What to do
Use strict photoprotection, adjust UVA dosing conservatively and monitor the skin for erythema or burns. Consider an alternative to chlorpromazine during phototherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Chlorpromazine with Methoxsalen?
MediHelp rates the interaction as moderate. Chlorpromazine and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is a photosensitizing phenothiazine, and methoxsalen is used with UVA light to induce photosensitivity. Combined use can increase the risk of severe phototoxic skin reactions, burns and eye damage.
How serious is the interaction between Chlorpromazine and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use strict photoprotection, adjust UVA dosing conservatively and monitor the skin for erythema or burns. Consider an alternative to chlorpromazine during phototherapy.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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