Drug interactions
Chlorpromazine + Oliceridine
Severity: Major
Chlorpromazine and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with sedating antipsychotics can cause profound sedation, respiratory depression, hypotension, coma and death. Chlorpromazine adds CNS depressant and alpha-blocking hypotensive effects to those of oliceridine.
What this interaction means in plain words
Chlorpromazine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism (oliceridine) and chlorpromazine's sedative effects, with additive hypotension.
What to do
Reserve the combination for patients in whom other options are inadequate, using the lowest doses and shortest duration. Monitor closely for sedation, respiratory depression and hypotension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Chlorpromazine with Oliceridine?
MediHelp rates the interaction as major. Chlorpromazine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with sedating antipsychotics can cause profound sedation, respiratory depression, hypotension, coma and death. Chlorpromazine adds CNS depressant and alpha-blocking hypotensive effects to those of oliceridine.
How serious is the interaction between Chlorpromazine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients in whom other options are inadequate, using the lowest doses and shortest duration. Monitor closely for sedation, respiratory depression and hypotension.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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