Drug interactions
Chlorpromazine + Orphenadrin
Severity: Moderate
Chlorpromazine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is sedating and strongly anticholinergic, and orphenadrine adds to both effects. The combination may cause marked drowsiness, confusion, constipation, urinary retention and tachycardia.
What this interaction means in plain words
Chlorpromazine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central sedation and muscarinic receptor blockade.
What to do
Monitor for oversedation and anticholinergic effects, and reduce doses if they occur. Be particularly careful in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Orphenadrin?
MediHelp rates the interaction as moderate. Chlorpromazine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is sedating and strongly anticholinergic, and orphenadrine adds to both effects. The combination may cause marked drowsiness, confusion, constipation, urinary retention and tachycardia.
How serious is the interaction between Chlorpromazine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, and reduce doses if they occur. Be particularly careful in elderly patients.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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