Drug interactions
Chlorpromazine + Oxymorphone
Severity: Moderate
Chlorpromazine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use can cause marked sedation, hypotension and respiratory depression. Chlorpromazine's alpha-blocking and anticholinergic effects can add to opioid-related dizziness and constipation.
What this interaction means in plain words
Chlorpromazine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and hypotensive effects from opioid agonism and phenothiazine antagonism of dopamine, histamine and alpha-adrenergic receptors.
What to do
Start with reduced doses of both and titrate cautiously. Monitor sedation, blood pressure and respiratory rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Oxymorphone?
MediHelp rates the interaction as moderate. Chlorpromazine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use can cause marked sedation, hypotension and respiratory depression. Chlorpromazine's alpha-blocking and anticholinergic effects can add to opioid-related dizziness and constipation.
How serious is the interaction between Chlorpromazine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses of both and titrate cautiously. Monitor sedation, blood pressure and respiratory rate.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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