Drug interactions
Chlorpromazine + Pexidartinib
Severity: Major
Chlorpromazine and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib can cause serious liver injury, and chlorpromazine can also cause cholestatic hepatotoxicity. Using them together may increase the risk of liver damage.
What this interaction means in plain words
Chlorpromazine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity; the two drugs injure the liver by different mechanisms.
What to do
Avoid the combination where possible. If both are needed, monitor liver enzymes and bilirubin frequently and stop pexidartinib for significant elevations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Chlorpromazine with Pexidartinib?
MediHelp rates the interaction as major. Chlorpromazine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib can cause serious liver injury, and chlorpromazine can also cause cholestatic hepatotoxicity. Using them together may increase the risk of liver damage.
How serious is the interaction between Chlorpromazine and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are needed, monitor liver enzymes and bilirubin frequently and stop pexidartinib for significant elevations.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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