Drug interactions
Chlorpromazine + Procarbazine
Severity: Moderate
Chlorpromazine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine causes CNS depression and has weak monoamine oxidase inhibiting properties, so adding chlorpromazine can increase drowsiness and sedation. Blood pressure changes are also possible.
What this interaction means in plain words
Chlorpromazine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive central nervous system depression.
What to do
Monitor for oversedation and hypotension, and counsel patients to avoid driving or hazardous tasks. Lower the chlorpromazine dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Procarbazine?
MediHelp rates the interaction as moderate. Chlorpromazine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine causes CNS depression and has weak monoamine oxidase inhibiting properties, so adding chlorpromazine can increase drowsiness and sedation. Blood pressure changes are also possible.
How serious is the interaction between Chlorpromazine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and hypotension, and counsel patients to avoid driving or hazardous tasks. Lower the chlorpromazine dose if sedation is excessive.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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