Drug interactions
Chlorpromazine + Saxagliptin-metformin
Severity: Moderate
Chlorpromazine and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can raise blood glucose, particularly at higher doses, reducing the effect of antidiabetic drugs. Glycemic control may worsen when it is started and improve when it is stopped.
What this interaction means in plain words
Chlorpromazine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Antipsychotic-related reduced insulin secretion and increased insulin resistance oppose glucose-lowering therapy.
What to do
Monitor glucose when starting, changing or stopping chlorpromazine. Adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Chlorpromazine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can raise blood glucose, particularly at higher doses, reducing the effect of antidiabetic drugs. Glycemic control may worsen when it is started and improve when it is stopped.
How serious is the interaction between Chlorpromazine and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting, changing or stopping chlorpromazine. Adjust antidiabetic doses accordingly.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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