Drug interactions
Chlorpromazine + Tamsulosin
Severity: Moderate
Chlorpromazine and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine inhibits CYP2D6 and has its own alpha-blocking activity. The combination may raise tamsulosin levels and cause additive orthostatic hypotension, dizziness and falls.
What this interaction means in plain words
Chlorpromazine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by chlorpromazine plus additive alpha-1 adrenergic blockade.
What to do
Monitor orthostatic blood pressure, especially in older patients. Lower the tamsulosin dose or choose an alternative if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Tamsulosin?
MediHelp rates the interaction as moderate. Chlorpromazine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine inhibits CYP2D6 and has its own alpha-blocking activity. The combination may raise tamsulosin levels and cause additive orthostatic hypotension, dizziness and falls.
How serious is the interaction between Chlorpromazine and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure, especially in older patients. Lower the tamsulosin dose or choose an alternative if hypotension occurs.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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