Drug interactions
Chlorpromazine + Tiotropium
Severity: Moderate
Chlorpromazine and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has notable anticholinergic activity that adds to tiotropium's effects. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
What this interaction means in plain words
Chlorpromazine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Tiotropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity, especially in elderly patients and those with glaucoma or prostatic hypertrophy. Consider alternatives if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Tiotropium?
MediHelp rates the interaction as moderate. Chlorpromazine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has notable anticholinergic activity that adds to tiotropium's effects. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
How serious is the interaction between Chlorpromazine and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in elderly patients and those with glaucoma or prostatic hypertrophy. Consider alternatives if symptoms develop.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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