Drug interactions
Chlorpromazine + Tranylcypromine
Severity: Moderate
Chlorpromazine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine causes alpha-blockade and hypotension, and MAO inhibitors can independently cause orthostatic hypotension. Together hypotension and sedation may be more pronounced, and extrapyramidal effects may be worsened.
What this interaction means in plain words
Chlorpromazine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive hypotensive, sedative and anticholinergic pharmacodynamic effects.
What to do
Monitor blood pressure including orthostatic readings and titrate slowly. Reduce the dose of either agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Tranylcypromine?
MediHelp rates the interaction as moderate. Chlorpromazine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine causes alpha-blockade and hypotension, and MAO inhibitors can independently cause orthostatic hypotension. Together hypotension and sedation may be more pronounced, and extrapyramidal effects may be worsened.
How serious is the interaction between Chlorpromazine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings and titrate slowly. Reduce the dose of either agent if symptomatic hypotension occurs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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