Drug interactions
Chlorpropamide + Fenofibrate
Severity: Minor
Chlorpropamide and Fenofibrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may modestly improve or alter glycemic control, and the combination with a sulfonylurea has been associated with hypoglycemia. Protein-binding displacement is a theoretical contributor and the effect is generally small.
What this interaction means in plain words
Chlorpropamide and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Fenofibrate belongs to Cardiovascular.
Why it happens
Possible additive glucose-lowering effect and protein-binding displacement; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping fenofibrate. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Fenofibrate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Fenofibrate?
MediHelp rates the interaction as minor. Chlorpropamide and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fibrates may modestly improve or alter glycemic control, and the combination with a sulfonylurea has been associated with hypoglycemia. Protein-binding displacement is a theoretical contributor and the effect is generally small.
How serious is the interaction between Chlorpropamide and Fenofibrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fenofibrate. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
