Drug interactions
Chlorpropamide + Vasopressin
Severity: Minor
Chlorpropamide and Vasopressin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpropamide enhances the renal antidiuretic response to vasopressin. This can increase water retention and, in susceptible patients, cause dilutional hyponatremia.
What this interaction means in plain words
Chlorpropamide and Vasopressin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Vasopressin belongs to Endocrine.
Why it happens
Chlorpropamide potentiates the action of vasopressin on renal collecting-duct V2 receptors, enhancing water reabsorption.
What to do
Monitor serum sodium and fluid status if the two are used together, particularly in elderly or hyponatremia-prone patients. Consider an alternative sulfonylurea if hyponatremia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpropamide
Other interactions of Vasopressin
- Carbamazepine + Vasopressin Moderate
- Clomipramine + Vasopressin Moderate
- Clozapine + Vasopressin Moderate
- Foscarnet + Vasopressin Moderate
- Haloperidol + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
Frequently asked questions
Can I take Chlorpropamide with Vasopressin?
MediHelp rates the interaction as minor. Chlorpropamide and Vasopressin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpropamide enhances the renal antidiuretic response to vasopressin. This can increase water retention and, in susceptible patients, cause dilutional hyponatremia.
How serious is the interaction between Chlorpropamide and Vasopressin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and fluid status if the two are used together, particularly in elderly or hyponatremia-prone patients. Consider an alternative sulfonylurea if hyponatremia develops.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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