Drug interactions
Chlorthalidone + Ertugliflozin-sitagliptin
Severity: Moderate
Chlorthalidone and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics can raise blood glucose and may weaken glycemic control in patients taking ertugliflozin-sitagliptin. Additive volume depletion and electrolyte disturbances can also occur with the SGLT2 inhibitor component.
What this interaction means in plain words
Chlorthalidone and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Thiazides cause hypokalemia and reduced insulin secretion and sensitivity, while ertugliflozin adds osmotic diuresis, so effects are additive on volume status.
What to do
Monitor blood glucose, blood pressure, volume status and electrolytes after starting or changing the diuretic. Adjust antidiabetic therapy or diuretic dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Chlorthalidone and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-type diuretics can raise blood glucose and may weaken glycemic control in patients taking ertugliflozin-sitagliptin. Additive volume depletion and electrolyte disturbances can also occur with the SGLT2 inhibitor component.
How serious is the interaction between Chlorthalidone and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure, volume status and electrolytes after starting or changing the diuretic. Adjust antidiabetic therapy or diuretic dose as needed.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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