Drug interactions
Chlorzoxazone + Prochlorperazine
Severity: Moderate
Chlorzoxazone and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause drowsiness and dizziness. Concurrent use may result in excessive sedation and impaired coordination, raising the risk of falls.
What this interaction means in plain words
Chlorzoxazone and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and monitor for oversedation. Advise patients to avoid alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Prochlorperazine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause drowsiness and dizziness. Concurrent use may result in excessive sedation and impaired coordination, raising the risk of falls.
How serious is the interaction between Chlorzoxazone and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation. Advise patients to avoid alcohol and driving until the response is known.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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