Drug interactions
Chlorzoxazone + Propofol
Severity: Moderate
Chlorzoxazone and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent anesthetic, and a concurrent sedating muscle relaxant can deepen sedation and increase the risk of hypotension and respiratory depression. This matters mainly in perioperative or procedural settings.
What this interaction means in plain words
Chlorzoxazone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Titrate propofol carefully to effect with continuous monitoring of oxygenation, ventilation and blood pressure. Inform the anesthesia team of recent chlorzoxazone use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorzoxazone and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorzoxazone
Other interactions of Propofol
Frequently asked questions
Can I take Chlorzoxazone with Propofol?
MediHelp rates the interaction as moderate. Chlorzoxazone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent anesthetic, and a concurrent sedating muscle relaxant can deepen sedation and increase the risk of hypotension and respiratory depression. This matters mainly in perioperative or procedural settings.
How serious is the interaction between Chlorzoxazone and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol carefully to effect with continuous monitoring of oxygenation, ventilation and blood pressure. Inform the anesthesia team of recent chlorzoxazone use.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
