Drug interactions
Cholestyramine + Ergocalciferol
Severity: Moderate
Cholestyramine and Ergocalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds bile acids and impairs absorption of fat-soluble vitamins including vitamin D. Long-term use may lead to lower vitamin D status.
What this interaction means in plain words
Cholestyramine and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Ergocalciferol belongs to Musculoskeletal.
Why it happens
Bile acid sequestration reduces micelle formation and intestinal absorption of vitamin D.
What to do
Give vitamin D at least 4 hours before cholestyramine. Monitor 25-hydroxyvitamin D levels in long-term users.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium citrate + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Ergocalciferol?
MediHelp rates the interaction as moderate. Cholestyramine and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds bile acids and impairs absorption of fat-soluble vitamins including vitamin D. Long-term use may lead to lower vitamin D status.
How serious is the interaction between Cholestyramine and Ergocalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give vitamin D at least 4 hours before cholestyramine. Monitor 25-hydroxyvitamin D levels in long-term users.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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