Drug interactions
Ciclesonide + Larotrectinib
Severity: Minor
Ciclesonide and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib has at most weak CYP3A4 inhibitory activity and is unlikely to alter ciclesonide exposure meaningfully.
What this interaction means in plain words
Ciclesonide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciclesonide belongs to Respiratory; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; not well established.
What to do
No specific action is required; monitor for signs of corticosteroid excess with long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Larotrectinib
Frequently asked questions
Can I take Ciclesonide with Larotrectinib?
MediHelp rates the interaction as minor. Ciclesonide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib has at most weak CYP3A4 inhibitory activity and is unlikely to alter ciclesonide exposure meaningfully.
How serious is the interaction between Ciclesonide and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor for signs of corticosteroid excess with long-term use.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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