Drug interactions
Ciclesonide + Nelfinavir
Severity: Moderate
Ciclesonide and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can raise exposure to the active metabolite of inhaled ciclesonide. Higher systemic corticosteroid levels may cause Cushing's syndrome and adrenal suppression, particularly with long-term use.
What this interaction means in plain words
Ciclesonide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Nelfinavir belongs to Anti Virals.
Why it happens
Nelfinavir inhibits CYP3A4-mediated metabolism of ciclesonide and its active metabolite, increasing systemic corticosteroid exposure.
What to do
Monitor for signs of corticosteroid excess and adrenal suppression during long-term use. Consider a corticosteroid less dependent on CYP3A4, such as beclomethasone, if prolonged coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Ciclesonide with Nelfinavir?
MediHelp rates the interaction as moderate. Ciclesonide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and can raise exposure to the active metabolite of inhaled ciclesonide. Higher systemic corticosteroid levels may cause Cushing's syndrome and adrenal suppression, particularly with long-term use.
How serious is the interaction between Ciclesonide and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and adrenal suppression during long-term use. Consider a corticosteroid less dependent on CYP3A4, such as beclomethasone, if prolonged coadministration is needed.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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