Drug interactions
Cilostazol + Enzalutamide
Severity: Moderate
Cilostazol and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can lower circulating cilostazol and its active metabolites. This may reduce the benefit of cilostazol for intermittent claudication.
What this interaction means in plain words
Cilostazol and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Enzalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 (and possibly CYP2C19) increases the metabolic clearance of cilostazol.
What to do
Monitor for loss of claudication symptom relief and consider an alternative if the response is lost. Avoid the combination if efficacy cannot be maintained.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Cilostazol with Enzalutamide?
MediHelp rates the interaction as moderate. Cilostazol and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can lower circulating cilostazol and its active metabolites. This may reduce the benefit of cilostazol for intermittent claudication.
How serious is the interaction between Cilostazol and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of claudication symptom relief and consider an alternative if the response is lost. Avoid the combination if efficacy cannot be maintained.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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