Drug interactions
Cilostazol + Tucatinib
Severity: Major
Cilostazol and Tucatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and may increase cilostazol exposure. This increases the risk of tachycardia, headache and other dose-related effects.
What this interaction means in plain words
Cilostazol and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cilostazol belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing cilostazol clearance.
What to do
Avoid if possible; otherwise reduce cilostazol to 50 mg twice daily and monitor heart rate and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cilostazol
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Cilostazol with Tucatinib?
MediHelp rates the interaction as major. Cilostazol and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tucatinib is a strong CYP3A inhibitor and may increase cilostazol exposure. This increases the risk of tachycardia, headache and other dose-related effects.
How serious is the interaction between Cilostazol and Tucatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce cilostazol to 50 mg twice daily and monitor heart rate and tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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