Drug interactions
Cimetidine + Disopyramide
Severity: Moderate
Cimetidine and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is partly metabolized by CYP3A4, and cimetidine may raise its levels. Cimetidine has also been reported to reduce disopyramide clearance, which may increase anticholinergic effects and proarrhythmic risk.
What this interaction means in plain words
Cimetidine and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Disopyramide belongs to Cardiovascular.
Why it happens
Cimetidine inhibits CYP3A4 and may reduce renal clearance of disopyramide.
What to do
Monitor ECG (QT/QRS) and anticholinergic effects such as dry mouth and urinary retention; reduce disopyramide dose if needed or use famotidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Cimetidine with Disopyramide?
MediHelp rates the interaction as moderate. Cimetidine and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide is partly metabolized by CYP3A4, and cimetidine may raise its levels. Cimetidine has also been reported to reduce disopyramide clearance, which may increase anticholinergic effects and proarrhythmic risk.
How serious is the interaction between Cimetidine and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QT/QRS) and anticholinergic effects such as dry mouth and urinary retention; reduce disopyramide dose if needed or use famotidine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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