Drug interactions
Cimetidine + Elagolix
Severity: Minor
Cimetidine and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix inhibits intestinal P-gp and may increase concentrations of P-gp substrates. Cimetidine is a P-gp substrate but has a wide margin of safety, so the effect is unlikely to matter.
What this interaction means in plain words
Cimetidine and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Elagolix belongs to Musculoskeletal.
Why it happens
Elagolix inhibits P-gp-mediated efflux of cimetidine.
What to do
No action is routinely required beyond awareness of cimetidine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Cimetidine with Elagolix?
MediHelp rates the interaction as minor. Cimetidine and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix inhibits intestinal P-gp and may increase concentrations of P-gp substrates. Cimetidine is a P-gp substrate but has a wide margin of safety, so the effect is unlikely to matter.
How serious is the interaction between Cimetidine and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is routinely required beyond awareness of cimetidine adverse effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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