Drug interactions
Cimetidine + Maraviroc
Severity: Minor
Cimetidine and Maraviroc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 and P-gp substrate. Cimetidine is a weak inhibitor and no dose change is recommended, so the effect is small.
What this interaction means in plain words
Cimetidine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Maraviroc belongs to Anti Virals.
Why it happens
Weak CYP3A4 inhibition by cimetidine slightly reducing maraviroc clearance.
What to do
No dose adjustment is usually needed; monitor for postural hypotension and hepatotoxicity as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Cimetidine with Maraviroc?
MediHelp rates the interaction as minor. Cimetidine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maraviroc is a CYP3A4 and P-gp substrate. Cimetidine is a weak inhibitor and no dose change is recommended, so the effect is small.
How serious is the interaction between Cimetidine and Maraviroc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for postural hypotension and hepatotoxicity as routine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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