Drug interactions
Cimetidine + Prochlorperazine
Severity: Minor
Cimetidine and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine inhibits several CYP enzymes, including CYP2D6, and may modestly increase prochlorperazine concentrations. Increased sedation or extrapyramidal effects are possible but not well documented.
What this interaction means in plain words
Cimetidine and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Prochlorperazine belongs to Central Nervous System.
Why it happens
Cimetidine inhibits hepatic CYP enzymes and reduces prochlorperazine metabolism.
What to do
Monitor for excess sedation, hypotension, and extrapyramidal symptoms. Consider an H2 blocker such as famotidine, which does not inhibit CYP enzymes, if the effects are troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Prochlorperazine?
MediHelp rates the interaction as minor. Cimetidine and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine inhibits several CYP enzymes, including CYP2D6, and may modestly increase prochlorperazine concentrations. Increased sedation or extrapyramidal effects are possible but not well documented.
How serious is the interaction between Cimetidine and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, hypotension, and extrapyramidal symptoms. Consider an H2 blocker such as famotidine, which does not inhibit CYP enzymes, if the effects are troublesome.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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