Drug interactions
Cimetidine + Vilazodone
Severity: Moderate
Cimetidine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may moderately increase vilazodone exposure through CYP3A4 inhibition. This can increase serotonergic and gastrointestinal adverse effects such as nausea, diarrhea and, rarely, serotonin toxicity.
What this interaction means in plain words
Cimetidine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Vilazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of vilazodone.
What to do
Monitor for serotonergic adverse effects and reduce vilazodone to 20 mg daily if intolerable effects occur. Consider famotidine as the acid-suppressing alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Cimetidine with Vilazodone?
MediHelp rates the interaction as moderate. Cimetidine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may moderately increase vilazodone exposure through CYP3A4 inhibition. This can increase serotonergic and gastrointestinal adverse effects such as nausea, diarrhea and, rarely, serotonin toxicity.
How serious is the interaction between Cimetidine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonergic adverse effects and reduce vilazodone to 20 mg daily if intolerable effects occur. Consider famotidine as the acid-suppressing alternative.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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