Drug interactions
Cinacalcet + Fedratinib
Severity: Moderate
Cinacalcet and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6, an enzyme that contributes to cinacalcet metabolism, and also inhibits CYP3A4 and CYP2C19. Cinacalcet exposure may rise, increasing the risk of hypocalcemia and nausea. Cinacalcet is itself a strong CYP2D6 inhibitor, so exposure to CYP2D6 substrates is also relevant.
What this interaction means in plain words
Cinacalcet and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP2D6 and CYP3A4, reducing cinacalcet clearance.
What to do
Monitor serum calcium and adverse effects, and reduce the cinacalcet dose if hypocalcemia occurs. Follow the fedratinib label for dose adjustments of CYP2D6 substrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Cinacalcet with Fedratinib?
MediHelp rates the interaction as moderate. Cinacalcet and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6, an enzyme that contributes to cinacalcet metabolism, and also inhibits CYP3A4 and CYP2C19. Cinacalcet exposure may rise, increasing the risk of hypocalcemia and nausea. Cinacalcet is itself a strong CYP2D6 inhibitor, so exposure to CYP2D6 substrates is also relevant.
How serious is the interaction between Cinacalcet and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and adverse effects, and reduce the cinacalcet dose if hypocalcemia occurs. Follow the fedratinib label for dose adjustments of CYP2D6 substrates.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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