Drug interactions
Cinacalcet + Fluconazole
Severity: Moderate
Cinacalcet and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is cleared partly by CYP3A4, and fluconazole inhibits this enzyme moderately. Exposure to cinacalcet may rise, increasing the risk of hypocalcemia and its consequences such as paresthesia, cramps and QT prolongation.
What this interaction means in plain words
Cinacalcet and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4 (and CYP2D6 is not the main route), reducing cinacalcet metabolism.
What to do
Monitor serum calcium and parathyroid hormone when fluconazole is started or stopped. Reduce the cinacalcet dose if hypocalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cinacalcet and Fluconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Fluconazole?
MediHelp rates the interaction as moderate. Cinacalcet and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is cleared partly by CYP3A4, and fluconazole inhibits this enzyme moderately. Exposure to cinacalcet may rise, increasing the risk of hypocalcemia and its consequences such as paresthesia, cramps and QT prolongation.
How serious is the interaction between Cinacalcet and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and parathyroid hormone when fluconazole is started or stopped. Reduce the cinacalcet dose if hypocalcemia develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
