Drug interactions
Cinacalcet + Vortioxetine
Severity: Moderate
Cinacalcet and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a strong CYP2D6 inhibitor, and CYP2D6 is a main pathway for vortioxetine clearance. Exposure to vortioxetine can rise substantially, increasing nausea and other dose-related adverse effects.
What this interaction means in plain words
Cinacalcet and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Vortioxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 by cinacalcet reduces vortioxetine metabolism.
What to do
Consider halving the vortioxetine dose when cinacalcet is started, and restore the original dose when cinacalcet is stopped. Monitor for nausea and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Vortioxetine?
MediHelp rates the interaction as moderate. Cinacalcet and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is a strong CYP2D6 inhibitor, and CYP2D6 is a main pathway for vortioxetine clearance. Exposure to vortioxetine can rise substantially, increasing nausea and other dose-related adverse effects.
How serious is the interaction between Cinacalcet and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider halving the vortioxetine dose when cinacalcet is started, and restore the original dose when cinacalcet is stopped. Monitor for nausea and tolerability.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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