Drug interactions
Cinnarizine + Dantrolene
Severity: Moderate
Cinnarizine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine can cause drowsiness, and with dantrolene the sedation and weakness may be increased. Alertness and coordination may be impaired.
What this interaction means in plain words
Cinnarizine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression via antihistaminic effects and dantrolene's central effects.
What to do
Counsel on drowsiness and driving, and lower doses if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Dantrolene?
MediHelp rates the interaction as moderate. Cinnarizine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine can cause drowsiness, and with dantrolene the sedation and weakness may be increased. Alertness and coordination may be impaired.
How serious is the interaction between Cinnarizine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and driving, and lower doses if sedation is troublesome.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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