Drug interactions
Cinnarizine + Oxycodone
Severity: Moderate
Cinnarizine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine has sedative antihistaminic properties, and with oxycodone it can intensify drowsiness and impair alertness. The risk is greater in older patients and at higher doses.
What this interaction means in plain words
Cinnarizine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1 antagonism and opioid effects.
What to do
Counsel patients about additive drowsiness and avoid driving; reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cinnarizine and Oxycodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Oxycodone?
MediHelp rates the interaction as moderate. Cinnarizine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine has sedative antihistaminic properties, and with oxycodone it can intensify drowsiness and impair alertness. The risk is greater in older patients and at higher doses.
How serious is the interaction between Cinnarizine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoid driving; reduce doses if excessive sedation occurs.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
