Drug interactions
Cinnarizine + Risperidone
Severity: Moderate
Cinnarizine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, and together they may produce greater sedation and psychomotor impairment. Cinnarizine can also cause extrapyramidal symptoms, which may be additive with risperidone's dopamine blockade, especially in older patients.
What this interaction means in plain words
Cinnarizine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-antihistamine activity and additive dopamine D2 antagonism.
What to do
Warn the patient about sedation and avoid driving or operating machinery until the response is known. Monitor for parkinsonian signs, particularly in elderly patients, and reduce or stop cinnarizine if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Risperidone?
MediHelp rates the interaction as moderate. Cinnarizine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, and together they may produce greater sedation and psychomotor impairment. Cinnarizine can also cause extrapyramidal symptoms, which may be additive with risperidone's dopamine blockade, especially in older patients.
How serious is the interaction between Cinnarizine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about sedation and avoid driving or operating machinery until the response is known. Monitor for parkinsonian signs, particularly in elderly patients, and reduce or stop cinnarizine if they appear.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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