Drug interactions
Cinnarizine + Sevoflurane
Severity: Moderate
Cinnarizine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine has antihistaminic and calcium channel blocking properties with sedative effects. Combined with sevoflurane it may increase sedation and contribute to hypotension.
What this interaction means in plain words
Cinnarizine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and possible additive vasodilation from calcium channel blockade.
What to do
Titrate sevoflurane to anesthetic depth monitoring and monitor blood pressure. Watch for delayed emergence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Sevoflurane?
MediHelp rates the interaction as moderate. Cinnarizine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine has antihistaminic and calcium channel blocking properties with sedative effects. Combined with sevoflurane it may increase sedation and contribute to hypotension.
How serious is the interaction between Cinnarizine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to anesthetic depth monitoring and monitor blood pressure. Watch for delayed emergence.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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