Drug interactions
Cinnarizine + Tramadol
Severity: Moderate
Cinnarizine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine has sedating antihistamine properties and can add to tramadol-related drowsiness and impaired coordination. Cinnarizine is also partly metabolized by CYP2D6, and both drugs may have additive effects in older adults.
What this interaction means in plain words
Cinnarizine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1 antagonism and opioid activity.
What to do
Advise patients to avoid driving and alcohol, and monitor older adults for oversedation and falls. Reduce doses if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Tramadol?
MediHelp rates the interaction as moderate. Cinnarizine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine has sedating antihistamine properties and can add to tramadol-related drowsiness and impaired coordination. Cinnarizine is also partly metabolized by CYP2D6, and both drugs may have additive effects in older adults.
How serious is the interaction between Cinnarizine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol, and monitor older adults for oversedation and falls. Reduce doses if drowsiness is troublesome.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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