Drug interactions
Cinnarizine + Trimipramine
Severity: Moderate
Cinnarizine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can cause more drowsiness, slowed reactions and impaired psychomotor performance than either alone. Cinnarizine also has antimuscarinic activity that may add to the anticholinergic burden of trimipramine.
What this interaction means in plain words
Cinnarizine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive sedative (H1 antagonism) and anticholinergic pharmacodynamic effects.
What to do
Counsel the patient to avoid driving and hazardous tasks until the response is known, and consider a lower starting dose of either drug. Monitor for excessive sedation, confusion and anticholinergic effects, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Trimipramine?
MediHelp rates the interaction as moderate. Cinnarizine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can cause more drowsiness, slowed reactions and impaired psychomotor performance than either alone. Cinnarizine also has antimuscarinic activity that may add to the anticholinergic burden of trimipramine.
How serious is the interaction between Cinnarizine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving and hazardous tasks until the response is known, and consider a lower starting dose of either drug. Monitor for excessive sedation, confusion and anticholinergic effects, especially in older patients.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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