Drug interactions
Ciprofloxacin + Leuprolide
Severity: Moderate
Ciprofloxacin and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide can prolong the QT interval, and ciprofloxacin has a small QT effect. Together they may increase the risk of torsades de pointes, especially in patients with other cardiac risk factors.
What this interaction means in plain words
Ciprofloxacin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation: androgen suppression alters cardiac repolarization and fluoroquinolones block hERG potassium channels.
What to do
Check a baseline ECG and correct electrolyte abnormalities. Consider an alternative antibiotic in patients with a prolonged QTc or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Ciprofloxacin with Leuprolide?
MediHelp rates the interaction as moderate. Ciprofloxacin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide can prolong the QT interval, and ciprofloxacin has a small QT effect. Together they may increase the risk of torsades de pointes, especially in patients with other cardiac risk factors.
How serious is the interaction between Ciprofloxacin and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct electrolyte abnormalities. Consider an alternative antibiotic in patients with a prolonged QTc or other QT-prolonging drugs.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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