Drug interactions
Amobarbital + Tasimelteon
Severity: Moderate
Amobarbital and Tasimelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce tasimelteon exposure through CYP3A4 induction. This may reduce its effect on circadian rhythm regulation.
What this interaction means in plain words
Amobarbital and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Tasimelteon belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases the metabolism of tasimelteon.
What to do
Avoid the combination if possible and monitor sleep-wake response. Use a non-inducing alternative to amobarbital where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Tasimelteon
Frequently asked questions
Can I take Amobarbital with Tasimelteon?
MediHelp rates the interaction as moderate. Amobarbital and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may reduce tasimelteon exposure through CYP3A4 induction. This may reduce its effect on circadian rhythm regulation.
How serious is the interaction between Amobarbital and Tasimelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and monitor sleep-wake response. Use a non-inducing alternative to amobarbital where possible.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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