Drug interactions
Ciprofloxacin + Tepotinib
Severity: Minor
Ciprofloxacin and Tepotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-gp and may raise concentrations of P-gp substrates. Ciprofloxacin is a weak P-gp substrate, so the effect is expected to be small.
What this interaction means in plain words
Ciprofloxacin and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibition of P-gp efflux may modestly raise ciprofloxacin exposure.
What to do
No routine adjustment is needed; watch for ciprofloxacin adverse effects such as GI or CNS symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Ciprofloxacin with Tepotinib?
MediHelp rates the interaction as minor. Ciprofloxacin and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits P-gp and may raise concentrations of P-gp substrates. Ciprofloxacin is a weak P-gp substrate, so the effect is expected to be small.
How serious is the interaction between Ciprofloxacin and Tepotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for ciprofloxacin adverse effects such as GI or CNS symptoms.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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