Drug interactions
Cisapride + Deutetrabenazine
Severity: Major
Cisapride and Deutetrabenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine has a small QT effect at recommended doses, but cisapride is a strong QT-prolonging agent. Combined use adds risk of torsades de pointes, particularly with bradycardia, electrolyte disturbance or higher deutetrabenazine exposure.
What this interaction means in plain words
Cisapride and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisapride belongs to Gastrointestinal Tract; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Avoid if possible; otherwise obtain an ECG, correct potassium and magnesium, and monitor for arrhythmia symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Cisapride with Deutetrabenazine?
MediHelp rates the interaction as major. Cisapride and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deutetrabenazine has a small QT effect at recommended doses, but cisapride is a strong QT-prolonging agent. Combined use adds risk of torsades de pointes, particularly with bradycardia, electrolyte disturbance or higher deutetrabenazine exposure.
How serious is the interaction between Cisapride and Deutetrabenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain an ECG, correct potassium and magnesium, and monitor for arrhythmia symptoms.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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