Drug interactions
Cisapride + Lenacapavir
Severity: Major
Cisapride and Lenacapavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor and may increase cisapride concentrations, with an effect persisting for months after the last subcutaneous dose. Raised cisapride levels increase the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Cisapride and Lenacapavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisapride belongs to Gastrointestinal Tract; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 metabolism of cisapride by lenacapavir.
What to do
Avoid the combination, including after stopping lenacapavir injections. If cisapride is essential, use ECG monitoring and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisapride and Lenacapavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Cisapride with Lenacapavir?
MediHelp rates the interaction as major. Cisapride and Lenacapavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lenacapavir is a moderate CYP3A4 inhibitor and may increase cisapride concentrations, with an effect persisting for months after the last subcutaneous dose. Raised cisapride levels increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Cisapride and Lenacapavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, including after stopping lenacapavir injections. If cisapride is essential, use ECG monitoring and correct electrolytes.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
