Drug interactions
Cisapride + Memantine-donepezil
Severity: Major
Cisapride and Memantine-donepezil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and cisapride can prolong the QT interval, and cisapride is strongly linked to torsades de pointes. Combined use increases the risk of life-threatening ventricular arrhythmia. Cisapride also has restricted availability.
What this interaction means in plain words
Cisapride and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisapride belongs to Gastrointestinal Tract; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QTc prolongation by blockade of cardiac repolarizing potassium currents.
What to do
Avoid the combination where possible and choose another prokinetic. If it cannot be avoided, obtain a baseline ECG, correct electrolytes, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Frequently asked questions
Can I take Cisapride with Memantine-donepezil?
MediHelp rates the interaction as major. Cisapride and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both donepezil and cisapride can prolong the QT interval, and cisapride is strongly linked to torsades de pointes. Combined use increases the risk of life-threatening ventricular arrhythmia. Cisapride also has restricted availability.
How serious is the interaction between Cisapride and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another prokinetic. If it cannot be avoided, obtain a baseline ECG, correct electrolytes, and monitor the QTc.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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