Drug interactions
Cisplatin + Paromomycin
Severity: Moderate
Cisplatin and Paromomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, but absorption may increase with inflamed or ulcerated bowel or renal impairment. Any systemic exposure could add to the nephrotoxicity and ototoxicity of cisplatin.
What this interaction means in plain words
Cisplatin and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Paromomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and ototoxicity if systemic aminoglycoside exposure occurs.
What to do
Monitor renal function and hearing if used together, particularly with intestinal mucosal damage or reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Cisplatin with Paromomycin?
MediHelp rates the interaction as moderate. Cisplatin and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral paromomycin is minimally absorbed, but absorption may increase with inflamed or ulcerated bowel or renal impairment. Any systemic exposure could add to the nephrotoxicity and ototoxicity of cisplatin.
How serious is the interaction between Cisplatin and Paromomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hearing if used together, particularly with intestinal mucosal damage or reduced renal function.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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