Drug interactions
Clarithromycin + Crofelemer
Severity: Minor
Clarithromycin and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer inhibits CYP3A4 in the gut in vitro, which could in theory modestly raise clarithromycin levels. Because crofelemer is minimally absorbed, systemic inhibition is unlikely and a clinically important effect has not been established.
What this interaction means in plain words
Clarithromycin and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible local intestinal CYP3A4 inhibition by crofelemer; the effect is theoretical.
What to do
No dose adjustment is needed. Monitor for clarithromycin adverse effects such as gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Clarithromycin with Crofelemer?
MediHelp rates the interaction as minor. Clarithromycin and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer inhibits CYP3A4 in the gut in vitro, which could in theory modestly raise clarithromycin levels. Because crofelemer is minimally absorbed, systemic inhibition is unlikely and a clinically important effect has not been established.
How serious is the interaction between Clarithromycin and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for clarithromycin adverse effects such as gastrointestinal upset.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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